C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/202, 167/221
C07D 239/66 (2006.01) C07D 401/12 (2006.01) C07H 19/06 (2006.01)
Patent
CA 1256860
Case 5993 KON 2A ABSTRACT Novel 5-pyrimidinecarboxamides and thiocarbox- amides useful for regressing or inhibiting the growth of leukemia and tumors. The compounds have the formula: Image wherein R1 and R2 are each independently hydrogen; alkyl, aryl, aralkyl, allyl, aralkenyl or aralkynyl, the alkyl, alkenyl or alkynyl moieties of which have from one to six carbon atoms, or a carbohydrate residue; R3 is hydrogen, C1-C4 alkyl or aryl; R4 is phenyl, naphthyl, benzyl, naphthylmethyl, thienyl, thienylmethyl or pyridyl; or phenyl, naphthyl, benzyl, naphthylmethyl, thienyl, thienylmethyl or pyridyl substituted with one or more of the following groups: hydroxy; halo; alkyl, alkoxy, alkylthio, haloalkyl or haloalkoxy having from one to four carbon atoms; carboxy; alkoxycarbonyl having from two to five carbon atoms; nitro; cyano; aryl; aryloxy; arylthio; benzyl; benzyloxy; naphthylmethyl; naphthylmethyloxy; thienyl; or thienylmethyl; W is oxygen or sulfur; X is sulfur or selenium; and Y and Z are each independently oxygen, sulfur or selenium; and the pharmacologically acceptable addition salts thereof.
470496
Brewer Arthur D.
Minatelli John A.
Gowling Lafleur Henderson Llp
Uniroyal Chemical Company Inc.
Uniroyal Chemical Ltd./uniroyal Chemical Ltee
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