5-pyrimidinecarboxamides and treatment of leukemia and...

Details 5-pyrimidinecarboxamides and treatment of leukemia and... 5-pyrimidinecarboxamides and treatment of leukemia and...

C - Chemistry, Metallurgy

07

D

167/202, 167/221

C07D 239/66 (2006.01) C07H 19/06 (2006.01)

Patent

CA 1256861

Case 5993 KON 1A ABSTRACT Novel 5-pyimidinecarboxamides useful for regressing or inhibiting the growth of leukemia and tumors in mammals. The compounds have the formula: Image wherein: R is hydrogen, 2- or 3- halo, 4-fluoro, 2-methyl, 4-(C1-C6 alkoxyl), 4-trifluoromethyl, or hydroxyl, and R1 is hydrogen; or R is 2-fluoro and R1 is 4-fluoro; or R is 2-methoxy and R1 is 5-methyl; and R2 and R3 are hydrogen atoms or carbohydrate residues; and the pharmacologically acceptable acid - addition salts thereof.

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