5-pyrrolidinylsulfonyl isatin derivatives

Details 5-pyrrolidinylsulfonyl isatin derivatives 5-pyrrolidinylsulfonyl isatin derivatives

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/403 (2006.01)

Patent

CA 2594770

The present invention relates to novel 5-pyrrolidinylsulfonyl isatin derivatives, non-peptidyl Caspase binding Radioligands (CbRs) and CbR- transporter conjugates derived from said isatin derivatives, diagnostic compositions comprising said compounds of the invention and their use for non- invasive diagnostic imaging.

L'invention porte sur de nouveaux dérivés de la 5-pyrrolidinylsulfonyl isatine, sur des radioligands non peptidyles de fixation de la caspase (CbRs) et sur des conjugués transporteurs des CbRs dérivés desdits dérivés d'isatine. L'invention porte également sur des compositions diagnostiques comprenant lesdits composants de l'invention et sur leur utilisation dans l'imagerie de diagnostic non invasifs.

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