5-quinolinone and imidazopyridine compounds and use thereof

Details 5-quinolinone and imidazopyridine compounds and use thereof 5-quinolinone and imidazopyridine compounds and use thereof

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/47 (2006.01) A61K 31/519 (2006.01) C07D 215/54 (2006.01) C07D 401/04 (2006.01) C07D 405/04 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2730280

5-Quinolinone and Imidazopyrimidine compounds are provided that are useful for inhibiting the efflux of any therapeutic agent that is a MRP1 substrate. Also provided is a method for screening to identify additional MRP1 inhibitors.

L'invention concerne des composés de 5-quinolinone et d'imidazopyridine qui sutilisent pour inhiber le flux d'un quelconque agent thérapeutique qui est un substrat de MRP1. L'invention concerne également un procédé de criblage pour identifier des inhibiteurs de MRP1 supplémentaires.

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