5-substituted 1(2'-deoxy-2'-substituted-...

C - Chemistry – Metallurgy – 07 – H

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C07H 19/06 (2006.01) C07H 19/12 (2006.01)

Patent

CA 1131626

ABSTRACT OF THE DISCLOSURE Pyrimidine nucleosides exhibiting anti-viral and anti-tumor effects have the formula Image wherein A is OR3, SR3, NR3R4 or NHacyl wherein R3 and R4 are the same or different and are hydrogen, lower alkyl of 1 to 7 carbon atoms, aralkyl, or aryl; NHacyl is alkanoyl or aroyl amide; B is oxygen or sulfur; X is halogen, alkylsulfonyl or arylsulfonyl; Y is halogen, amino, monoalkyl- or monoaralkylamino, dialkylamino, aminomethyl, hydroxymethyl, lower alkyl, aryl, aralkyl, vinyl and substituted vinyl or ethynyl and substituted ethynyl; Z is methyne or nitrogen; R1 and R2 are the same or different and are hydrogen acyl or aroyl. Process for preparing the same.

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