5-substituted 10-cyanomethylenethieno [3,4-b] benzazepines

C - Chemistry – Metallurgy – 07 – D

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C07D 495/04 (2006.01) A61K 31/55 (2006.01)

Patent

CA 1319687

ABSTRACT OF THE DISCLOSURE: Disclosed are 5-substituted 10-cyanomethylene- thieno[3,4-b]-benzazepines of the formula I Image ( I) where Rl, R2 and R3 are each hydrogen or halogen or alkyl, A is an amino radical -NR4R5 where R4 and R5 form, together with the nitrogen connecting them, a 5- to 7-membered saturated ring which may contain a nitrogen or oxygen as further hetero atom, it being possible for an additional nitrogen to be substituted by alkyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl or cycloalkylmethyl, alkynyl and additionally by oxygen in the form of an N-oxide, or A is an amino radical - NHR6 where R6 is aminoalkyl, it being possible for the amine nitrogen to be substituted by lower alkyl or to be a constituent of a 5- to 7-membered saturated ring which may contain a nitrogen or oxygen as further hetero atom, it being possible for a nitrogen which is present to be substituted by lower alkyl or hydroxyalkyl. These compounds and their physiologically tolerated acid addition salts are useful for treating psychological disturbances in a patient suffering therefrom.

567077

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