5-substituted benzoxazines

Details 5-substituted benzoxazines 5-substituted benzoxazines

C - Chemistry, Metallurgy

07

D

C07D 265/18 (2006.01) A61K 31/536 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2733709

The present invention is concerned with 5-substituted benzoxazine derivatives of formula (I), wherein X, R1 and R2 are as described herein, as well as their manufacture, pharmaceutical compositions containing them and their use as medicaments. The active compounds of the present invention are 5-HT5A receptor antagonists, useful in the prevention and/or treatment of depression, anxiety disorders, schizophrenia, panic disorders, agoraphobia, social phobia, obsessive compulsive disorders, post-traumatic stress disorders, pain, memory disorders, dementia, disorders of eating behaviors, sexual dysfunction, sleep disorders, abuse of drugs, motor disorders such as Parkinson's disease, psychiatric disorders or gastrointestinal disorders.

La présente invention concerne des dérivés de benzoxazine 5-substituées de formule (I); dans laquelle X, R1 et R2 sont tels que décrits dans le présent document, ainsi que leur fabrication, des compositions pharmaceutiques les contenant et leur utilisation en tant que médicaments. Les composés actifs de la présente invention sont des antagonistes du récepteur 5-HT5A, utiles pour la prévention et/ou le traitement de la dépression, des troubles de lanxiété, de la schizophrénie, des états de panique, de lagoraphobie, de la phobie sociale, des troubles obsessionnels compulsifs, des états de stress post-traumatique, de la douleur, des troubles de la mémoire, de la démence, des troubles du comportement alimentaire, des dysfonctionnements sexuels, des troubles du sommeil, de labus de drogues, des troubles moteurs tels que la maladie de Parkinson, des troubles psychiatriques ou des troubles gastro-intestinaux.

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