C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/242, 167/244
C07D 311/22 (2006.01) C07D 311/86 (2006.01) C07D 335/06 (2006.01) C07D 335/16 (2006.01) C07D 405/04 (2006.01)
Patent
CA 1244453
ABSTRACT OF THE DISCLOSURE Certain 5-substituted chromones and thiochromones and pharmacologically acceptable salts thereof are disclosed. The compounds possess antiallergic pro- perties and are represented by the formula: Image wherein: X is selected from the group consisting of -O-, -S-, and -SO2-; R1 and R2 are each independently H or lower alkyl having from 1 to 4 carbon atoms or together with C2 and C3 from a cyclohexane ring having the structure: Image wherein R3 and R4 are each independently H or a lower alkyl having from 1 to 4 carbon atoms. Also taught are valuable intermediates useful in the preparation of said 5-substituted chromones and thiochromones represented by the formula: Image wherein B is selected from the group consisting of - NHCOC(CH3)3, 1,3-oxazolinyl and -CONHR, wherein R is methyl, phenyl, or t-butyl; Y is selected from the group consisting of CO2H, CHO, CO2R' and COR', wherein R' is a lower alkyl having from 1 to 4 carbon atoms; and A is H or tetrahydropyran.
478839
Abram Trevor S.
Norman Peter
Warren Brian T.
Miles Laboratories Inc.
Osler Hoskin & Harcourt Llp
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