5-substituted-hydroxy picolinic acid derivatives

Details 5-substituted-hydroxy picolinic acid derivatives 5-substituted-hydroxy picolinic acid derivatives

C - Chemistry, Metallurgy

07

D

260/297

C07D 213/78 (2006.01) C07D 213/65 (2006.01) C07D 213/79 (2006.01) C07D 213/81 (2006.01)

Patent

CA 1115709

ABSTRACT OF THE DISCLOSURE 5-Substituted picolinic acid derivatives represented by the formula (I): Image (I) wherein Rl represents a straight or branched chain halogen- substituted alkyl group having 2 to 6 carbon atoms or a substituted phenyl group having the formula - Image wherein R3 and R4, which may be the same or different, each represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a nitro group, an amino group, an N-alkyl-substituted amino group, an acylamino group, an acetyl group, an acyloxy group, a hydroxy group or a halogen-substituted alkyl group or R3 and R4, when taken together, represent a polymethylene chain; and R2 represents an -OM group wherein M represents a hydrogen, sodium, potassium, calcium, aluminium or magnesium atom, a straight or branched chain or cyclic alkoxy group having 1 to 6 carbon atoms, an aminoalkoxy group, a phenoxy group, a.substituted phenoxy group, a 5-indanyloxy? group, an acyloxyalkyloxy group having the formula Image wherein R5 represents a hydrogen atom or a methyl group and R6 represents a lower alkyl group having 1 to 6 carbon atoms, a phenyl group or a substituted phenyl group, or an amino group represented by the formula Image wherein R7 and R8, which may be the same or different, each represents a hydrogen atom, a lower alkyl group, or a phenyl group which are useful as anti-hypertensive agents, a process for preparing the above 5-substituted picolinic acid derivatives, and anti-hyper- tensive compositions containing the same. 5-Indanyl ester of 5-alkoxy-picolinic acid represented by the formula (A): . Image (A) wherein Ra represents an alkyl group having 1 to 6 carbon atoms, which are useful as anti-hypertensive agents, a process for preparing 5-indanyl ester of 5-alkoxy-picolinic acid, and anti-hypertensive compositions containing the 5-indanyl ester of 5-alkoxy-picolinic acid.

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