5-substituted isoquinoline derivative

Details 5-substituted isoquinoline derivative 5-substituted isoquinoline derivative

C - Chemistry, Metallurgy

07

D

C07D 217/02 (2006.01) A61K 31/472 (2006.01) A61K 31/4725 (2006.01) A61P 11/00 (2006.01) A61P 11/06 (2006.01) A61P 27/02 (2006.01) A61P 27/06 (2006.01) A61P 43/00 (2006.01) C07D 217/04 (2006.01) C07D 217/22 (2006.01) C07D 217/24 (2006.01) C07D 217/26 (2006.01) C07D 401/12 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2493230

A compound represented by the following formula (1): (1) wherein R1 represents hydrogen, halogeno, etc.; R2 represents hydrogen, halogeno, C1-6 alkyl, etc.; R3 represents, e.g., -O-X-C(A1)(A11)-C(A2)(A21)-N(A31)(A3) (X represents propylene, etc.; A11 and A21 each represents hydrogen or C1-6 alkyl; A31 represents C1-6 hydroxyalkyl or hydrogen; and A1, A2, and A3 each represents hydrogen, C1-6 alkyl, etc.) or a salt of the compound. The compound or salt has myosin regulatory light-chain phosphorylation inhibitory activity and is useful in treatments for diseases to which contraction of various cells relates.

Cette invention se rapporte à un composé représenté par la formule (I), où R?1¿ représente hydrogène, halogéno, etc.; R?2¿ représente hydrogène, halogéno, alkyle C¿1-6?, etc.; R?3¿ représente par exemple O-X-C(A?1¿) (A?11¿)-C(A?2¿) (A?21¿)-N(A?31¿) (A?3¿) (où X représente propylène, etc.; A?11¿ et A?21¿ représentent chacun hydrogène ou alkyle C¿1-6?; A?31¿ représente hyroxyalkyle C¿1-6? ou hydrogène; et A?1¿, A?2¿ et A?3¿ représentent chacun hydrogène, alkyle C¿1-6?, etc.) ou un sel de ce composé. Ce composé ou son sel possèdent une action inhibitrice de la phosphorylation à chaîne légère régulatrice de la myosine et il peut servir dans le traitement de maladies auxquelles est liée la contraction de diverses cellules.

Affiliated with

Also associated with

Rating

5-substituted isoquinoline derivative does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 5-substituted isoquinoline derivative, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 5-substituted isoquinoline derivative will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1470665