5-substituted octahydroindolizine analgesics compounds and...

C - Chemistry – Metallurgy – 07 – D

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C07D 471/04 (2006.01) A61K 31/395 (2006.01)

Patent

CA 1288430

5-SUBSTITUTED OCTAHYDROINDOLIZINE ANALGESICS COMPOUNDS AND 7-KETO INTERMEDIATES ABSTRACT Octahydroindolizidines and corresponding ketones of the formulae (I) and (II): (I) Image Image (II) where A is a 3-7 carbon or hetero-containing ring, R1 is a substituent, n is 0-6 and x is 0-3. Also, pharmaceutical compositions for treating pain containing (I) or (II) and methods for synthesis and use as well as novel intermediates in the synthesis.

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