5-(substituted phenyl)hydantoins

Details 5-(substituted phenyl)hydantoins 5-(substituted phenyl)hydantoins

C - Chemistry, Metallurgy

07

D

260/305.3, 260/3

C07D 233/76 (2006.01) C07D 233/78 (2006.01) C07D 405/12 (2006.01) C07D 407/12 (2006.01)

Patent

CA 1203241

5- (SUBSTITUTED PHENYL)HYDANTOINS ABSTRACT OF THE DISCLOSURE A series of 5-(substituted phenyl)hydantoins and pharmaceutically acceptable salts thereof are aldose reductase inhibitors useful as agents for treatment of chronic diabetic complications and processes for preparation of said compounds. The hydantoins have the formula: Image I wherein each of X and Y is hydrogen, fluoro, chloro, bromo, (C1-6)alkyl, (C1-6)alkoxy, trifluoromethyl, amino or nitro; Z is S(O)mR or S02NHR1; R is (C1-6)alkyl, chloro, methoxymethyl or Image ; m is 0, 1 or 2, with the proviso that when R is chloro, m is 2; R1 is hydrogen, furfuryl, Image ,(C1-6)alkyl, omega-substituted (C2-6)alkyl wherein the substituent is hydroxy or dimethylamino; R4 is hydrogen, fluoro or chloro; n is an integer of from 1 to 4; p is 0 or an integer of from 1 to 4; and each of R2 and R3 is hydrogen, fluoro,chloro, bromo, (C1-6)alkyl, (C1-6)alkoxy, amino or nitro. P.C.(Ph) 6581

440069

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