5-substituted pyranone compounds and their use as...

Details 5-substituted pyranone compounds and their use as... 5-substituted pyranone compounds and their use as...

C - Chemistry, Metallurgy

07

D

260/356.1, 260/3

C07D 405/02 (2006.01) C07D 257/04 (2006.01) C07D 309/38 (2006.01) C07D 309/40 (2006.01)

Patent

CA 1142944

ABSTRACT Compounds are described of the formula- Image in which R1 is COOR5, CONHR5, cyano, 5-tetrazolyl or 5-tetrazolylaminocarbonyl, where R5 is hydrogen or C1-6 alkyl; R2 is hydrogen or C1-6 alkyl; R3 is a group of the formula Image where m is 0 or 1, Z is O, S, SO, SO2 or CO, and R6 is phenyl optionally substituted by one or more groups selected from halogen, C1-4 alkyl, C3-6 cycloalkyl, C1-4 alkoxy, benzyloxy, hydroxy, nitro, C1-4 alkylthio, C1-4 alkylsulphinyl, C1-4 alkylsulphonyl, amino and NHR7 where R7 is C2-6 acyl; and R4 is hydrogen, C1-6 alkyl or halogen; and salts thereof. These compounds have pharmaceutical properties and in particular are useful in the treatment of immediate hypersensitivity conditions such as asthma.

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