5-substituted quinazolinone derivatives

Details 5-substituted quinazolinone derivatives 5-substituted quinazolinone derivatives

C - Chemistry, Metallurgy

07

D

C07D 239/95 (2006.01) A61K 31/517 (2006.01) A61P 13/00 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2530450

Compounds which are alpha- 1A/B adrenoceptor antagonists and which are represented by Formula (I), wherein Q is a monocyclic or bicyclic optionally- substituted heterocyclic ring as defined in the Specification; Z is -C(=O)- or- S(=O)2-; R and R' are lower alkyl; R5 is halogen, cyano, hydroxy, -R6, or - OR6; and R6 is alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, heterocyclo, or substituted heterocyclo; and pharmaceutically- acceptable salts, hydrates, prodrugs, and isomers thereof.

La présente invention a trait à des composés qui sont des antagonistes du récepteur adrénergique alpha-1A/B représentés par la formule (I), dans laquelle : Q est un noyau hétérocyclique monocyclique ou bicyclique éventuellement substitué tel que défini dans la description ; Z est -C(=O)- ou-S(=O)¿2?-; R et R' sont alkyle inférieur ; R?5¿ est halogène, cyano, hydroxy , -R?6¿ ou -OR?6 ¿; et R?6¿ est alkyle, alkyle substitué, aryle, aryle substitué, hétéroaryle, hétéroaryle substitué, cycloalkyle, cycloalkyle substitué, hétérocyclo, ou hétérocyclo substitué ; ainsi que leurs sels, hydrates, prodrogues, et isomères pharmaceutiquement acceptables.

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