5-substituted tetralones as inhibitors of ras farnesyl...

Details 5-substituted tetralones as inhibitors of ras farnesyl... 5-substituted tetralones as inhibitors of ras farnesyl...

C - Chemistry, Metallurgy

07

D

C07D 233/54 (2006.01) A61K 31/4164 (2006.01) A61P 43/00 (2006.01) C07D 233/91 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/06 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/06 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2405696

The present invention provides novel 5-substituted tetralones of Formulas (I), (II), (III) and (IV) and pharmaceutically acceptable salts, esters, amides, and prodrugs thereof, which are useful for treating and preventing uncontrolled or abnormal proliferation of tissues, such as cancer, atherosclerosis, restenosis, and psoriasis. Specifically, the present invention relates to compounds that inhibit the farnesyl transferase enzyme.

L'invention concerne des tétralones 5-substituées de formules (I, II, III et IV) ainsi que des sels, des esters, des amides et leurs promédicaments pharmaceutiquement acceptables, utiles dans le traitement et la prévention de la prolifération incontrôlée ou anormale de tissu, comme c'est le cas dans le cancer, l'athérosclérose, la resténose et le psoriasis. La présente invention porte en particulier sur des composés inhibiteurs de l'enzyme de la farnesyl transférase.

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