5-substituted uridine derivatives and intermediates for...

Details 5-substituted uridine derivatives and intermediates for... 5-substituted uridine derivatives and intermediates for...

C - Chemistry, Metallurgy

07

H

167/125, 260/210

C07H 23/00 (2006.01) A61K 31/70 (2006.01)

Patent

CA 1326848

Abstract This invention provides a 5-substituted uridine derivative of the formula Image wherein X is F or CF3, R1 and R2 each represent a group -OSi-(R4)(R5)(R6) (wherein R4, R5 and R6 represent C1-C10 alkyl or the like), OH, aminoacyloxy group wherein the amino group may be substituted with lower alkyl group or carboxylalkylcarbonyloxy group, R3 is a group -OSi- (R4)(R5)(R6), H, OH, aminoacyloxy group wherein the amino group may be substituted with lower alkyl group or carboxylalkylcarbonyloxy group, and at least one of R1, R2 and R3 is a group -OSi-(R4)(R5)(R6), with the proviso that when X is fluorine atom, R3 is not hydrogen, and an intermediate for the preparation thereof, preparation processes of the derivative and anti-tumor agent containing the derivative as an active ingredient.

608481

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