5-sulphanyl-4h-1,2,4-triazole derivatives and their use as...

Details 5-sulphanyl-4h-1,2,4-triazole derivatives and their use as... 5-sulphanyl-4h-1,2,4-triazole derivatives and their use as...

C - Chemistry, Metallurgy

07

D

C07D 249/12 (2006.01) A61K 31/4196 (2006.01) A61P 5/00 (2006.01) A61P 25/00 (2006.01) A61P 35/00 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01) C07D 403/12 (2006.01) C07D 405/04 (2006.01) C07D 405/12 (2006.01) C07D 409/04 (2006.01) C07D 417/04 (2006.01)

Patent

CA 2468184

The invention concerns novel 5-sulphanyl-4<I>H</I>-1,2,4-triazole derivatives of formula (I), wherein: R¿1?, R¿2? and R¿3? represent variable groups and the methods for preparing them by liquid-phase parallel synthesis processes. Said product exhibit good affinity for certain sub-types of somatostatin receptors; they are particularly useful for treating pathological conditions or diseases wherein one (or more) somatostatin receptors is (are) involved. The invention also concerns pharmaceutical compositions containing said products and their use for preparing a medicine.

La présente demande a pour objet de nouveaux dérivés de 5-sulfanyl-4H-1,2,4- triazoles de formule (I), dans laquelle R1, R2 et R3 représentent divers groupes variables et leurs procédés de préparation par des méthodes de synthèse en parallèle en phase liquide. Ces produits ayant une bonne affinité pour certains sous-types de récepteurs de la somatostatine, ils sont particulièrement intéressants pour traiter les états pathologiques ou les maladies dans lesquels un (ou plusieurs) des récepteurs de la somatostatine est (sont) impliqué(s). L'invention concerne également des compositions pharmaceutiques contenant lesdits produits et leur utilisation pour la préparation d'un médicament.

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