5-trityloxymethyl-oxazolidinones and process for the...

Details 5-trityloxymethyl-oxazolidinones and process for the... 5-trityloxymethyl-oxazolidinones and process for the...

C - Chemistry, Metallurgy

07

D

C07D 263/22 (2006.01) C07D 263/24 (2006.01)

Patent

CA 2418200

A method for preparing protected, preferably chiral, 5-trityloxymethyl-oxazolidinone having the following formula: (see formula 1) in one step directly from optically active 3-hydroxy-4-trityloxybutyramide is described. Oxazolidinones are an important class of molecules in the pharmaceutical industry especially in the areas of antimicrobials and behavioral disorders.

L'invention concerne un procédé de préparation de 5-trityloxyméthyl-oxazolidinone protégée, de préférence chirale, en une seule étape directement à partir de 3-hydroxy-4-trityloxybutyramide optiquement actif. Les oxazolidinones constituent une classe importante de molécules dans l'industrie pharmaceutique, notamment dans les domaines des antimicrobiens et des troubles du comportement.

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