5-urea substituted naphthalimide derivatives, methods of...

C - Chemistry – Metallurgy – 07 – D

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C07D 221/14 (2006.01) A61K 31/473 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2651197

Novel ureyl-substituted naphthalimide derivatives, pharmaceutically acceptable salts thereof and solvates thereof, are useful for making pharmaceutical compositions for the treatment of cell proliferative diseases such as cancer. The invention also provides methods for making such derivatives through hydrolysis of known compounds.

L'invention concerne de nouveaux dérivés de naphtalimide à substituant uréyle, leurs sels et leurs solvates pharmaceutiquement acceptables utiles pour la préparation de compositions pharmaceutiques pour le traitement de maladies liées à la prolifération cellulaire, telles que le cancer. L'invention concerne également des procédés de préparation de tels dérivés par hydrolyse de composés connus.

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