5h-[1]benzopyrano [2,3-d] pyrimidine derivatives, processes...

Details 5h-[1]benzopyrano [2,3-d] pyrimidine derivatives, processes... 5h-[1]benzopyrano [2,3-d] pyrimidine derivatives, processes...

C - Chemistry, Metallurgy

07

D

167/219, 260/242

C07D 491/052 (2006.01) A61K 31/505 (2006.01) C07D 491/04 (2006.01) C07D 491/153 (2006.01)

Patent

CA 1249814

- 1 - S u m m a r y The invention relates to 5H-[1]-benzopyrano-[2,3-d]pyrimi- dine derivatives of the general formula I Image (I), wherein R1 and R2, which may be the same or different, represent a hydrogen or halogen atom, a hydroxyl group or a straight-chain or branched alkoxy group with up to four carbon atoms, or together form an alkylenoxy- or alkylendioxy- group with 1 to 3 carbon atoms or represent a condensed aromatic ring, R3 represents an optionally substituted phenyl radical, R4 an alkyl group containing 1 to 8 carbon atoms or the radical Image wherein R5 and R6, which may be the same or different, represent a hydrogen atom, a straight-chain or branched alkyl group with up to 6 carbon atoms or together with the nitrogen atom to which they are attached form a saturated 5- or 6 membered ring optionally containing further heteroatoms and n represents the figures 2 to 6, and their pharmacologically acceptable salts with organic or anorganic acids. The compounds according to formula I may be prepared by means of a new chemical process and have a protective effect similar to that of Cimetidine, but do not exhibit the undesired side effects of antise- cretory agents. The invention is based on a new mucopro- tective mode of action which prevents that lesions of the mucous membrane epithelium arise.

464282

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