5h-cyclopenta[d]pyrimidines as akt protein kinase inhibitors

Details 5h-cyclopenta[d]pyrimidines as akt protein kinase inhibitors 5h-cyclopenta[d]pyrimidines as akt protein kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 239/70 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01) C07D 401/04 (2006.01) C07D 401/10 (2006.01) C07D 409/04 (2006.01) C07D 417/04 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2711782

Compounds of Formula I are useful for inhibiting AKT protein kinases. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed. Formula (I).

La présente invention concerne des composés représentés par la formule (I) qui se révèlent utiles pour inhiber les protéines kinases Akt. La présente invention concerne également des méthodes d'utilisation des composés représentés par la formule (I), ainsi que des stéréoisomères et des sels pharmaceutiquement acceptables de ces composés, pour le diagnostic, la prévention ou le traitement in vitro, in situ, et in vivo de tels troubles, ou de pathologies associées, dans des cellules mammaliennes. Formule (I).

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