5h-thiazolo[3,2-a]pyrimidin-5-one derivatives

Details 5h-thiazolo[3,2-a]pyrimidin-5-one derivatives 5h-thiazolo[3,2-a]pyrimidin-5-one derivatives

C - Chemistry, Metallurgy

07

D

C07D 513/04 (2006.01) A61K 31/505 (2006.01)

Patent

CA 2195578

The present invention relates to new 5H-thiazolo[3,2-a]pyrimidin-5-one derivatives having formula (I): wherein Ar is phenyl optionally substituted by one or two groups selected from halogen, alkyl having from 1 to 4 carbon atoms, methylendioxy, alkoxy having from 1 to 4 carbon atoms, and trifluoromethyl; and R is a group selected from (a) or (b) as well as their pharmaceutically acceptable addition salts, which are useful in the treatment of psychosis, schizophrenia and anxiety. This invention also discloses methods and intermediates for their preparation and pharmaceutical compositions containing them.

Nouveaux dérivés de 5H-thiazolo[3,2-a]pyrimidin-5-one de formule (I) dans laquelle Ar est phényle éventuellement substitué par un ou deux groupes choisis parmi halogène, alkyle ayant 1 à 4 atomes de carbone, méthylendioxy, alcoxy ayant de 1 à 4 atomes de carbone et trifluorométhyle; et R est un groupe choisi entre (a) ou (b), ainsi que leurs sels d'addition pharmaceutiquement acceptables, qui sont utiles dans le traitement de la psychose, de la schizophrénie et de l'anxiété. La présente invention concerne également des procédés et des intermédiaires pour leur préparation et des compositions pharmaceutiques les contenant.

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