5h-thiazolo[3,2-a]pyrimidine derivatives

Details 5h-thiazolo[3,2-a]pyrimidine derivatives 5h-thiazolo[3,2-a]pyrimidine derivatives

C - Chemistry, Metallurgy

07

D

C07D 513/04 (2006.01) A61K 31/505 (2006.01) C07D 239/22 (2006.01) C07D 239/40 (2006.01)

Patent

CA 2243234

The invention is concerned with compounds of the general formula (see formula I) wherein R1 signifies hydrogen, lower alkyl, phenyl or benzyl, R2 signifies lower alkyl, lower alkoxy, -O(CH2)n N(R13)(R14), -(CH2)n N(R13)(R14) or -N(R15)(CH2)n N(R13)(R14), R3-R12 signify hydrogen, halogen, trifluoromethyl, lower alkyl, cyclo-alkyl, lower alkoxy, hydroxy, nitro, cyano, -N(R13)2, phenyl, phenyloxy, benzyl or benzyloxy, or R6 and R7 together signify a benzene ring, R13-R15 signify hydrogen, lower alkyl or cycloalkyl and n signifies 1-5, as well as their pharmaceutically acceptable salts. These compounds are suitable for the control or prevention of acute and/or chronic neurological disorders such as restricted brain function caused by bypass operations or transplants, poor blood supply to the brain, spinal cord injuries, head injuries, hypoxia caused by pregnancy, cardiac arrest, hypoglycaemia, Alzheimer's disease,Huntington's chorea, ALS, dementia caused by AIDS, eye injuries, retinopathy, cognitive disorders, idiopathic parkinsonism or parkinsonism caused by medicaments as well as conditions which lead to glutamate-deficiency functions, such as e.g. muscle spasms, convulsions, migraine, urinary incontinence, nicotine addiction, psychoses, opiate addiction, anxiety, vomiting, chronic pain, dyskinesia and depressions.

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