(5r)-1,5-diaryl-4,5-dihydro-1h-pyrazole-3-carboxamidine...

Details (5r)-1,5-diaryl-4,5-dihydro-1h-pyrazole-3-carboxamidine... (5r)-1,5-diaryl-4,5-dihydro-1h-pyrazole-3-carboxamidine...

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/4155 (2006.01) A61K 31/454 (2006.01) A61P 25/00 (2006.01) C07D 403/12 (2006.01)

Patent

CA 2721908

This invention concerns (5R)-1,5-diaryl-4,5-dihydro-1H-pyrazole-3- carboxamidine derivatives as cannabinoid-CB1 receptor antagonists, methods for the prepara-tion of these compounds, novel intermediates useful for the synthesis of said dihydropyrazole derivatives, methods for the preparation of these intermediates, pharmaceutical composi-tions containing one or more of these dihy-dropyrazole derivatives as active ingredient, as well as the use of these pharmaceutical compo-sitions for the treatment of psychiatric and neu-rological disorders involving cannabinoid re-ceptors. The compounds have the formula (I) wherein the symbols have the meanings given in the specification.

Cette invention porte sur des dérivés de (5R)-1,5-diaryl-4,5-dihydro-1H-pyrazole-3-carboxamidine comme antagonistes des récepteurs aux cannabinoïdes CB1, sur des procédés de fabrication de ces composés, sur de nouveaux intermédiaires utiles pour la synthèse desdits dérivés de dihydropyrazole, sur des procédés de fabrication de ces intermédiaires, sur des compositions pharmaceutiques contenant un ou plusieurs de ces dérivés de dihydropyrazole comme ingrédient actif, ainsi que sur l'utilisation de ces compositions pharmaceutiques pour le traitement de troubles psychiatriques et neurologiques mettant en jeu les récepteurs aux cannabinoïdes. Les composés sont représentés par la formule (I) dans laquelle les symboles ont les significations données dans la description.

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