(5s) -3-[(s)-fluoro (4-trifluoromethylphenyl)...

Details (5s) -3-[(s)-fluoro (4-trifluoromethylphenyl)... (5s) -3-[(s)-fluoro (4-trifluoromethylphenyl)...

C - Chemistry, Metallurgy

07

D

C07D 215/20 (2006.01) A61K 31/47 (2006.01)

Patent

CA 2591486

The invention relates to novel tetrahydroquinoline derivatives of formula (I), wherein R1 represents cyclohexyl or cyclopentyl, R2 and R3 each represent methyl or jointly form a cyclobutane, and R4 represents cyclopentyl or isopropyl, the salts and solvates thereof, and the solvates of said salts. Also disclosed are a method for the production thereof, the use thereof on its own or in combinations for the treatment and/or prevention of diseases, and the use thereof for producing medicaments, particularly as a cholesterol ester transfer protein (CETP) inhibitor in order to treat and/or prevent cardiovascular diseases, especially hypolipoproteinemia, dyslipidemia, hypertriglyceridemia, hyperlipidemia, hypercholesterolemia, and arteriosclerosis.

L'invention concerne de nouveaux dérivés de tétrahydroquinoléine de formule (I) dans laquelle R1 représente un cyclohexyle ou cyclopentyle, R2 et R3 désignent respectivement un méthyle ou forment conjointement un cyclobutane, et R4 représente un cyclopentyle ou isopropyle, ou les sels, les solvates, et les solvates des sels de ces composés. Cette invention concerne également un procédé de production de ces dérivés, leur utilisation seuls ou en association pour traiter et/ou prévenir des maladies, ainsi que leur utilisation pour produire des médicaments, en particulier leur utilisation en tant qu'inhibiteurs de la protéine de transfert des esters de cholestérol (CETP) pour traiter et/ou prévenir des maladies cardiovasculaires, notamment des hypolipoproteinémies, dyslipidémies, hypertriglycéridémies, hyperlipidémies, hypercholestérolémies, et artérioscléroses.

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