6-¬1-hydroxyethyl|-2-sr.sup.8-1-methyl-1-...

Details 6-¬1-hydroxyethyl|-2-sr.sup.8-1-methyl-1-... 6-¬1-hydroxyethyl|-2-sr.sup.8-1-methyl-1-...

C - Chemistry, Metallurgy

07

D

167/208, 260/299

C07D 477/00 (2006.01) A61K 31/395 (2006.01) C07D 207/12 (2006.01) C07D 211/46 (2006.01) C07D 211/54 (2006.01) C07D 279/12 (2006.01) C07D 295/205 (2006.01) C07D 477/20 (2006.01)

Patent

CA 1274514

TITLE OF THE INVENTION 6-[1-HYDROXYETHYL]-2-SR8-1-METHYL-1-CARBA- DETHIAPEN-2-EM-3-CARBOXYLIC ACIDS ABSTRACT OF THE DISCLOSURE Disclosed are antibiotic 6-[1-hydroxy- ethyl]-2-SR8-1-methyl-1-carbadethiapen-2-em-3-car- boxylic acids and their pharmaceutically acceptable salts and esters (I): Image I wherein: R8 is Image ;and wherein n and m are independently selected from 0, 1, 2, 3, 4; X is -NR: and Y is -R, or -NRR: and wherein R is independently selected from hydrogen, alkyl, alkenyl, alkynyl. (having 1-6 carbon atoms): cycloalkyl and cycloalkenyl (having 3-6 carbon atoms): and heterocyclyl, heteroary. (having 3-6 ring atoms, one or more of which is N, O or S). Also disclosed are processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds and methods of treatment comprising administering such compounds and compositions when antibiotic effect is indicated.

479274

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