6,11 bicyclic erythromycin derivatives

C - Chemistry – Metallurgy – 07 – H

Patent

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Details

C07H 17/08 (2006.01) A61K 31/7048 (2006.01) A61P 31/04 (2006.01) C07H 17/00 (2006.01)

Patent

CA 2483875

The present invention discloses compounds of formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

L'invention concerne des composés de formule (I), ou des sels, des esters ou des promédicaments pharmaceutiquement acceptables de ceux-ci qui présentent des propriétés antibactériennes. Par ailleurs, l'invention concerne des compositions pharmaceutiques contenant les composés précités, qui sont destinées à être administrées à un sujet ayant besoin d'un traitement antibiotique. De plus, l'invention concerne des méthodes de traitement d'une infection bactérienne chez un sujet, qui consistent à lui administrer une composition pharmaceutique renfermant les composés de l'invention. L'invention concerne enfin un procédé de préparation de ces composés.

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