6,11-bridged biaryl macrolides

C - Chemistry – Metallurgy – 07 – H

Patent

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Details

C07H 17/08 (2006.01) A61K 31/7048 (2006.01) A61K 31/7052 (2006.01)

Patent

CA 2699733

The present invention discloses compounds of formula I, II or, or pharmaceutically acceptable salts, esters, or prodrugs thereof: (formulas) which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

Cette invention concerne des composés de formule I, II ou leurs promédicaments, sels ou esters pharmaceutiquement acceptables : (formules) qui présentent des propriétés antibactériennes. L'invention concerne également des compositions pharmaceutiques comprenant les composés susmentionnés à administrer chez un sujet nécessitant un traitement antibiotique. L'invention concerne par ailleurs des procédés permettant de traiter une infection bactérienne chez un sujet en lui administrant une composition pharmaceutique comprenant les composés de l'invention. L'invention concerne en outre un procédé permettant de fabriquer les composés de l'invention.

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