6-11 bridged oxime erythromycin derivatives

C - Chemistry – Metallurgy – 07 – H

Patent

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Details

C07H 17/08 (2006.01) A01N 43/22 (2006.01) A61K 31/7042 (2006.01)

Patent

CA 2605295

The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof (see formula I) which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes processes by which to make the compounds of the present invention.

L'invention se rapporte à des composés de formule (I) ou à leurs sels pharmaceutiquement acceptables, leurs esters ou promédicaments (voir formule (I)) qui possèdent des propriétés antibactériennes. L'invention concerne également des compositions pharmaceutiques renfermant lesdits composés et qui sont destinées à être administrées à un sujet nécessitant un tel traitement antibiotique. L'invention concerne également des méthodes de traitement d'une infection bactérienne chez un sujet par administration d'une composition pharmaceutique renfermant les composés selon l'invention. L'invention concerne également des procédés de fabrication des composés selon l'invention.

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