6,11-dihydrodibenz[b,e]oxepin-acetic acids and derivatives

Details 6,11-dihydrodibenz[b,e]oxepin-acetic acids and derivatives 6,11-dihydrodibenz[b,e]oxepin-acetic acids and derivatives

C - Chemistry, Metallurgy

07

D

260/355.5

C07D 313/04 (2006.01) C07C 59/70 (2006.01) C07C 65/24 (2006.01) C07D 313/12 (2006.01)

Patent

CA 1153384

6,11-DIHYDRODIBENZ[b,e]OXEPIN-ACETIC ACIDS AND DERIVATIVES ABSTRACT OF THE DISCLOSURE 6,11-Dihydrodibenz[b,e]oxepin-acetic acids and deriva- tives having the general formula Image are prepared by multi-step sequences. X is C=O, CHCl, CHBr, CH2 or CHOR4; Y is alkyl or alkoxy of 1 to 4 carbon atoms, halogen or trifluoremethyl; n is 0, 1, 2 or 3; Z is COOR5, CH2OR5, CONR? or CONHOR5; and R1 - R5 are hydrogen or alkyl of 1 to 4 carbon atoms. These compounds and the physiologically tolerable salts thereof are useful as antiinflammatory and analgesic agents.

208542

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