C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/14 (2006.01) A61K 31/4709 (2006.01) A61K 31/517 (2006.01) A61P 29/00 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01)
Patent
CA 2659696
The present invention is directed to novel 6-lH-imidazo-2- aryl and 2-heteroaryl quinazoline and quinoline of Formula (I), corresponding salts and solvates thereof, to a process for their preparation and to the use of this compounds and corresponding pharmaceutical composition for the treatment of pain and inflammatory related disorders. Compounds of the invention have been proven highly effective in the pharmacological treatment of both inflammatory and neuropathic pain, in addition to striking anti-inflammatory properties. Their effectiveness in interfering with COX-2 and inflammatory cytokines expressions and production, highlights them as interesting compounds also for the treatment of cancer in addition to several inflammatory diseases.
L'invention concerne des composés de 6-lH-imidazo-2-aryle et 2-hétéroaryle quinazoline et quinoléine de formule (I), leurs sels et solvates correspondants, leur procédé de préparation et leur utilisation ainsi que la composition pharmaceutique correspondante destinée au traitement de la douleur et des troubles inflammatoires associés. Les composés de l'invention se révèlent être particulièrement efficaces dans le traitement pharmacologique des douleurs inflammatoires et névropathiques et possèdent également d'excellentes propriétés anti-inflammatoires. Leur efficacité en tant que composés empêchant les expressions des cytokines inflammatoires et COX-2 et leur production en font des composés dignes d'intérêt utilisés également pour traiter non seulement diverses maladies inflammatoires mais également le cancer.
Caselli Gianfranco
Giordani Antonio
Makovec Francesco
Mandelli Stefano
Mazzari Silvio
Macrae & Co.
Rottapharm S.p.a.
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