C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/47 (2006.01)
Patent
CA 2179264
The subject invention relates to compounds having structure (I) wherein: (a) R is unsubstituted C1-C3alkanyl or alkenyl; (b) R' is selected from unsubstituted C1-C3 alkanyl or alkenyl; unsubstituted C1-C3alkylthio or alkoxy; hydroxy; thiol; and halo; and (c) R'' is selected from hydrogen; unsubstituted C1-C3 alkanyl or alkenyl; methyl monosubstituted with hydroxy, thiol or amino; unsubstituted C1-C3alkylthio or alkoxy; amino; unsubstituted amide; unsubstituted or C1-C3 substituted amido; halo; unsubstituted sulfoxide; unsubstituted sulfonyl and cyano; pharmaceutical compositions containing such compounds, and the use of such compounds for preventing or treating respiratory, ocular; and/or gastrointestinal disorders.
L'invention concerne des composés ayant la structure (I) dans laquelle: (a) R représente C¿1?-C¿3?alcanyle ou alkényle non substitués; (b) R' est choisi parmi C¿1?-C¿3?alcanyle ou alkényle non substitué, C¿1?-C¿3?alkylthio ou alcoxy non substitué, hydroxy, thiol, et halo; et (c) R" est choisi parmi hydrogène, C¿1?-C¿3?alcanyle ou alkenyle non substitué, méthyle monosubstitué avec hydroxyle, thiol ou amino, C¿1?-C¿3?alkylthio ou alkoxy non substitué, amino, amide non substitué, amido C¿1?-C¿3? substitué ou non substitué, halo, sulfoxide non substitué, sulfonyle non substitué, et cyano. L'invention concerne aussi des compositions pharmaceutiques contenant lesdits composés, ainsi que l'utilisation de tels composés pour la prévention ou le traitement de troubles respiratoires, oculaires et/ou gastro-intestinaux.
Ares Jeffrey Joseph
Cupps Thomas Lee
Maurer Peter Julian
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