6-(3-aza-bicyclo[3.1.0]hex-3-yl)-2-phenyl-pyrimidines

Details 6-(3-aza-bicyclo[3.1.0]hex-3-yl)-2-phenyl-pyrimidines 6-(3-aza-bicyclo[3.1.0]hex-3-yl)-2-phenyl-pyrimidines

C - Chemistry, Metallurgy

07

D

C07D 403/14 (2006.01) A61K 31/506 (2006.01) A61P 7/00 (2006.01) A61P 9/00 (2006.01)

Patent

CA 2756542

The present invention relates to 6-(3-aza-bicyclo[3.1.0]hex-3-yl)-2-phenyl- pyrimidine derivatives and their use as P2Y12 receptor antagonists in the treatment and/or prevention of peripheral vascular, of visceral-, hepatic- and renal-vascular, of cardiovascular and of cerebrovascular diseases or conditions associated with platelet aggregation, including thrombosis in humans and other mammals.

L'invention porte sur des dérivés 6-(3-azabicyclo[3.1.0]hex-3-yl)-2-phénylpyrimidines et sur leur utilisation comme antagonistes du récepteur P2Y12 dans le traitement et/ou la prévention de maladies vasculaires périphériques, viscérales, hépatiques et vasculaires rénales, cardiovasculaires et cérébrovasculaires ou d'affections associées à l'agrégation plaquettaire, dont la thrombose chez l'homme et d'autres mammifères.

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