6-(3-pyridyl-methylamino)purine derivatives and their use as...

C - Chemistry – Metallurgy – 07 – D

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C07D 473/00 (2006.01) A61K 31/52 (2006.01) A61P 17/06 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) C07D 473/16 (2006.01)

Patent

CA 2492659

The present invention relates to compounds of formula (1) or pharmaceutically acceptable salts thereof, wherein one of R1 and R2 is methyl, ethyl or isopropyl, and the other is H; R3 and R4 are each independently H, branched or unbranched C1-C6 alkyl, or aryl, and wherein at least one of R3 and R4 is other than H; R5 is a branched or unbranched C1-C5 alkyl group or a C1-C6 cycloalkyl group, each of which may be optionally substituted with one or more OH groups; R6, R7, R8 and R9 are each independently H, halogen, NO2, OH, OMe, CN, NH2, COOH, CONH2, or SO2NH2. A further aspect of the invention relates to pharmaceutical compositions comprising compounds of formula (1), and the use of said compounds in treating proliferative disorders, viral disorders, stroke, alopecia, CNS disorders, neurodegenerative disorders, or diabetes.

La présente invention se rapporte à de nouveaux composés représentés par la formule (I), ou à des sels pharmaceutiquement acceptables de ces derniers. Dans ladite formule, R?1¿ ou R?2¿ représente méthyle, éthyle ou isopropyle, et l'autre représente H ; R?3¿ et R?4¿, pris indépendamment, représentent chacun H, un alkyle C¿1?-C¿6? ramifié ou linéaire, ou aryle, au moins l'un des deux ne représentant pas H ; R?5¿ représente un groupe alkyle C¿1?-C¿5? ramifié ou linéaire ou un groupe cycloalkyle C¿1?-C¿6?, un ou plusieurs groupes OH pouvant éventuellement être substitués à chacun d'entre eux ; R?6¿, R?7¿, R?8¿ et R?9¿, pris indépendamment, représentent chacun H, halogène, NO¿2?, OH, OMe, CN, NH¿2?, COOH, CONH¿2?, ou SO¿2?NH¿2?. Dans un autre aspect, l'invention a trait à des compositions pharmaceutiques contenant les composés représentés par la formule (I), et à l'utilisation desdits composés dans le traitement de troubles prolifératifs, de troubles viraux, d'accidents vasculaires cérébraux, de l'alopécie, de troubles du système nerveux central, de troubles neurodégénératifs, ou de diabètes.

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