C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 311/04 (2006.01) C07D 307/79 (2006.01) C07D 311/58 (2006.01) C07D 313/08 (2006.01) C07D 319/18 (2006.01) C07D 321/10 (2006.01) C07D 405/04 (2006.01)
Patent
CA 2336089
Disclosed are compounds of formula (I) or the pharmaceutically acceptable acid addition salts thereof, wherein: R1, R2, R3, R4 and R5 are the same or different and represent hydrogen, halogen, C1-C6 alkyl, C1-C6 alkoxy, C1-C4 alkylthio, hydroxy, amino, mono- or di(C1-C6)alkylamino, cyano, nitro, trifluoromethyl or trifluoromethoxy; and X is oxygen, a bond, C1-C2 alkylene or methyleneoxy, which compounds are useful for the treatment and/or prevention of neuropsychological disorders including, but not limited to, schizophrenia, mania, dementia, depression, anxiety, compulsive behavior, substance abuse, Parkinson-like motor disorders and motion disorders related to the use of neuroleptic agents.
L'invention concerne des composés de la formule (I) ou des sels d'addition acides pharmaceutiquement acceptables desdits composés. Dans ladit formule, R¿1?, R¿2?, R¿3?, R¿4? et R¿5? sont identiques ou différents et représentent hydrogène, halogène, alkyle C¿1?-C¿6?, alcoxy C¿1?-C¿6?, alkylthio C¿1?-C¿4?, hydroxy, amino, mono ou dialkylamino(C¿1?-C¿6?), cyano, nitro, trifluorométhyle ou trifluorométhoxy; et X est oxygène, une liaison, alkylène C¿1?-C¿2?, ou méthylèneoxy. Ces composés sont utiles pour le traitement et/ou la prévention de troubles neuropsychologiques, y compris, entre autres, la schizophrénie, la manie, la démence, la dépression, l'anxiété, le comportement compulsif, l'abus de substances psychoactives, les troubles moteurs de type parkinsonien et les troubles moteurs liés à l'usage de neuroleptiques antipsychotiques.
Thurkauf Andrew
Tran Jennifer N.
Mbm & Co.
Neurogen Corporation
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