C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61K 31/4985 (2006.01) A61K 31/519 (2006.01) A61P 9/00 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07D 209/00 (2006.01) C07D 209/10 (2006.01) C07D 221/00 (2006.01) C07D 239/00 (2006.01) C07D 241/00 (2006.01) C07D 487/04 (2006.01)
Patent
CA 2412462
The present invention provides compounds of Formula (I) wherein Q1, Q2, Q3, Q4, Y1, Y2, and Z are as defined in the description, and pharmaceutically acceptable salts thereof, and C1-C8 alkyl esters thereof, which are useful for the treatment of diseases responsive to the inhibition of the enzyme 15- lipoxygenase. Thus, the compounds of Formula (I) and their pharmaceuticalyl acceptable salts are useful for treating diseases with an inflammatory component, including atherosclerosis, diseases involving chemotaxis of monocytes, inflammation, stroke, coronary artery disease, asthma, arthritis, colorectal cancer, and psoriasis.
La présente invention concerne des composés de formule (I), dans laquelle Q¿1?, Q¿2?, Q¿3?, Q¿4?, Y¿1?, Y¿2?, et Z sont tels que définis dans le descriptif, et des sels correspondants acceptables pharmaceutiquement, et des esters alkyles C¿1?-C¿8? correspondants, utilisés dans le traitement de maladies sensibles à l'inhibition de la lipoxygénase 15. Ainsi, on utilise les composés de la formule (I) et leurs sels acceptables pharmaceutiquement dans le traitement de maladies présentant un aspect inflammatoire, notamment l'athérosclérose, des maladies impliquant la chimiotaxie de monocytes, des inflammations, des accidents vasculaires cérébraux, des maladies de l'artère coronaire, l'asthme, l'arthrite, le cancer colorectal, et le psoriasis.
Picard Joseph Armand
Roark William Howard
Sliskovic Drago Robert
Sim & Mcburney
Warner-Lambert Company
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