6.5-pyrrolopiperidine tachykinin receptor antagonists

Details 6.5-pyrrolopiperidine tachykinin receptor antagonists 6.5-pyrrolopiperidine tachykinin receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61K 31/4545 (2006.01) A61P 13/00 (2006.01)

Patent

CA 2690737

The present invention is directed to certain hydroxymethyl ether hydroisoindoline compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, LUTS, depression, and anxiety.

L'invention concerne certains composés hydroisoindolines d'hydroxyméthyl éther qui sont utiles en tant qu'antagonistes du récepteur de neurokinine-1 (NK-1), et des inhibiteurs de tachykinine et en particulier de la substance P. L'invention concerne également des formulations pharmaceutiques comprenant ces composés comme principes actifs et l'utilisation des composés et de leurs formulations dans le traitement de certains troubles, y compris l'émèse, l'incontinence urinaire, les SBAU, la dépression et l'anxiété.

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