C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/437 (2006.01) A61K 31/4985 (2006.01) A61K 31/5025 (2006.01) A61K 31/519 (2006.01) A61K 31/53 (2006.01) A61P 11/06 (2006.01) A61P 17/06 (2006.01) A61P 25/00 (2006.01) A61P 35/00 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2561950
Compounds of the formula (I) and pharmaceutically acceptable salts thereof, wherein XI, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer, inflammation, psoriasis, allergy/asthma, disease and conditions of the immune system, disease and conditions of the central nervous system.
La présente invention a trait à des composés de formule (I), dans laquelle X¿1?, X¿2?, X¿3?, X¿4?, X¿5?, X¿6?, X¿7?, R?1¿, et Q?1¿ sont tels que définis dans la description et leurs sels pharmaceutiquement acceptables, inhibiteurs de l'enzyme IGF-1R et utiles pour le traitement et/ou la prévention de maladies à hyperprolifération telles que le cancer, l'inflammation, le psoriasis, l'allergie/l'asthme, des maladies et conditions du système immunitaire, des maladies et conditions du système nerveux central.
Arnold Lee D.
Cesario Cara
Coate Heather
Crew Andrew Philip
Dong Hanqing
Cassan Maclean
Osi Pharmaceuticals Inc.
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