C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61K 31/55 (2006.01) A61P 1/00 (2006.01) A61P 11/06 (2006.01) A61P 11/14 (2006.01) A61P 17/00 (2006.01) A61P 25/04 (2006.01)
Patent
CA 2646977
Certain tetrahydro-pyrimidoazepine compounds are described, which are useful as TRPV1 modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by TRPV1. Thus, the compounds may be administered to treat, e.g., pain, itch, cough, asthma, or inflammatory bowel disease.
La présente invention concerne un certain nombre de composés de tétrahydro-pyrimidoazépine, qui sont utiles comme modulateurs du TRPV1. Lesdits composés peuvent être utilisés dans des compositions pharmaceutiques et des procédés permettant le traitement d'états maladifs, de troubles, et de pathologies médiés par le TRPV1. En conséquence, les composés peuvent être administrés pour traiter la douleur, le prurit, la toux, l'asthme, ou la maladie intestinale inflammatoire, entre autres.
Allison Brett D.
Branstetter Bryan James
Breitenbucher James Guy
Hack Michael D.
Hawryluk Natalie A.
Janssen Pharmaceutica N.v.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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