6,7,8,9-tetrahydropyrido[1,2-a] indole derivatives

Details 6,7,8,9-tetrahydropyrido[1,2-a] indole derivatives 6,7,8,9-tetrahydropyrido[1,2-a] indole derivatives

C - Chemistry, Metallurgy

07

D

167/231, 260/272

C07D 471/04 (2006.01) A61K 31/44 (2006.01)

Patent

CA 1296730

Abstract A pharmaceutical composition comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof: Image (I) wherein: R1 is hydrogen, C1-6 alkyl, C1-6 alkoxy or halogen; R2 and R3 are both hydrogen or together represent a bond; R4 is hydrogen and R5 is hydrogen or R4 and R5 together represent an oxo group; R6 is hydrogen; C1-6 alkyl; C3-7 cycloalkyl; C3-7 cycloalkyl-C1-4 alkyl; phenyl or phenyl C1-7 alkyl in which the phenyl moiety is optionally substituted by one or two of halogen, ortho-nitro, meta-or para-methoxy, methyl or NR8R9 wherein R8 and R9 are independently hydrogen or C1-6 alkyl or R8 and R9 together are C2-6 polymethylene, or 3,4-disubstituted by methylenedioxy or ethylenedioxy; or monocyclic heteroaryl-C1-4 alkyl, aliphatic heterocyclyl or aliphatic heterocyclyl-C1-4 alkyl of up to six ring atoms, the heteroatom(s) being - 2 - selected from oxygen, sulphur or nitrogen, any amino nitrogen heteroatom optionally C1-4 alkyl substituted; and R7 is hydrogen or C1-4 alkyl; and a pharmaceutically acceptable carrier.

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