6,7-benzomorphan derivatives and their production

Details 6,7-benzomorphan derivatives and their production 6,7-benzomorphan derivatives and their production

C - Chemistry, Metallurgy

07

D

260/237.85

C07D 221/26 (2006.01) C07D 211/70 (2006.01)

Patent

CA 1040629

NOVEL 6,7-BENZOMORPHAN DERIVATIVES AND THEIR PRODUCTION Abstract of the Disclosure A novel 2-substituted-6,7-benzomorphan derivative of the formula: Image and its pharmaceutically accpetable acid addition salts, which are useful as non-addicting analgesics and antitussives and can be prepared, for example, by reacting a 2-unsubstituted-6,7- benzomorphan derivative of the formula: Image with the reactive derivative of an alcohol of the formula: A'-Q , optionally followed by elimination of the protective group in the resulting product [wherein R1 is hydrogen, lower alkyl or C2-C6 alkanoyl; R2 and R3 are each lower alkyl and; A is lower alkyl, cyano(lower)alkyl, a benzoyl(lower)alkyl group, or substituted benzoyl(lower)alkyl, a phenyl(lower)alkyl group, a lower alkenyl group or a cyclo(lower)alkyl(lower)alkyl group; and A' is a group as mentioned in A or a substituted or unsub- stituted benzoyl(lower)alkyl of which the carbonyl group is protected in the form of a ketal].

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