C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/4162 (2006.01) A61P 29/00 (2006.01) C07D 209/00 (2006.01)
Patent
CA 2496500
The present invention relates to compounds which are capable of preventing the extracellular release of inflammatory cytokines, said compounds, including all enantiomeric and diasteriomeric forms and pharmaceutically acceptable salts thereof, have the formula (I) wherein R1 is substituted aryl; R4 is substituted or unsubstituted aryl or heteroaryl.
La présente invention a trait à des composés qui sont capables d'inhiber la libération extracellulaire de cytokines inflammatoires, lesdits composés, y compris leurs formes enantiomères et diastéréomères et leurs sels pharmaceutiquement acceptables, correspondent à la formule (I), dans laquelle : R?1¿ est aryle substitué ; R?4¿ est aryle ou hétéroaryle substitué ou non substitué.
Brugel Todd Andrew
Clark Michael Phillip
Golebiowski Adam
Laufersweiler Matthew John
Sabat Mark P.
The Procter & Gamble Company
Torys Llp
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