6, 7 -dihydro- 5h- pyrrolo [3, 4-d] pyrimidin-4-yl]...

Details 6, 7 -dihydro- 5h- pyrrolo [3, 4-d] pyrimidin-4-yl]... 6, 7 -dihydro- 5h- pyrrolo [3, 4-d] pyrimidin-4-yl]...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 9/00 (2006.01) A61P 11/00 (2006.01) A61P 19/02 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2744343

Compounds are disclosed that have formula I: where A, B, L1, W, Y, R1, and R3 are as defined herein. The com- pounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non- limiting example, pain, anxiety, depression, inflammation, cognitive disorders, weight and eating disorders, Parkinson's disease, Alzheimer's disease, spasticity, addiction, glaucoma, and others.

La présente invention concerne des composés de formule I, dans laquelle A, B, L1, W, Y, R1 et R3 sont tels que définis. Ces composés et leurs compositions pharmaceutiques sont utiles dans la prévention et le traitement de divers états chez les mammifères, notamment les humains, notamment et de manière non restrictive, la douleur, lanxiété, la dépression, l'inflammation, les troubles cognitifs, les troubles du poids et de l'alimentation, la maladie de Parkinson, la maladie d'Alzheimer, la spasticité, la dépendance et le glaucome.

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