6,9-bridged erythromycin derivatives

Details 6,9-bridged erythromycin derivatives 6,9-bridged erythromycin derivatives

C - Chemistry, Metallurgy

07

H

C07H 17/08 (2006.01) A61K 31/70 (2006.01)

Patent

CA 2301643

Novel multicyclic erythromycin compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity having formula (I), (II), or (III), compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, as well as a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention.

Cette invention concerne de nouveaux composés d'érythromycine à plusieurs cycles ainsi que leurs sels et leurs esters pharmaceutiquement acceptables qui présentent une activité antibactérienne. Ces composés ont pour formule (I), (II) ou (III). On décrit également des compositions contenant une quantité thérapeutiquement efficace d'un composé de l'invention en combinaison avec un support pharmaceutiquement acceptable, ainsi qu'un procédé permettant de traiter les infections bactériennes qui consiste à administrer à un mammifère une composition pharmaceutique contenant une quantité thérapeutiquement efficace d'un composé de l'invention.

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