6-acrylamidopenicillins and 7-acrylamidocephalosporins

C - Chemistry – Metallurgy – 07 – D

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C07D 499/44 (2006.01) C07D 307/46 (2006.01) C07D 307/54 (2006.01) C07D 333/22 (2006.01) C07D 333/24 (2006.01) C07D 499/00 (2006.01) C07D 501/20 (2006.01)

Patent

CA 1056373

ABSTRACT OF THE DISCLOSURE Novel antibiotic compounds which are 7.beta.-acrylamidoceph- 3-em-4-carboxylic acids, and non-toxic derivatives thereof wherein the acrylamido group has the structure Image wherein A is aryl group and B is a substituted or unsubstituted lower alkyl, lower alkenyl or lower alkynyl group; or an aryl, cycloalkyl or cycloalkenyl group. These compounds possess antibacterial activity against gram-positive and gram-negative organisms coupled with stability to .beta.-lactamases. The invention further relates to the administration of the compounds.

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