C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 237/10 (2006.01) A61K 31/50 (2006.01) A61K 31/535 (2006.01) C07D 237/04 (2006.01) C07D 237/12 (2006.01) C07D 237/14 (2006.01) C07D 237/20 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 409/04 (2006.01) C07D 413/12 (2006.01) C07D 451/02 (2006.01) C07D 451/04 (2006.01) C07D 487/04 (2006.01)
Patent
CA 2048162
- 29 - PATENT APPLICATION entitled: 6-Alkylpyridazine derivatives, method of preparation and pharmaceutical compositions in which they are present in the names of: Robert BOIGEGRAIN Roger BRODIN Jean Paul KAN Dominique OLLIERO Camille-Georges WERMUTH Assignee: SANOFI ABSTRACT OF THE DISCLOSURE The present invention relates to pyridazine derivatives of formula : Image (I) in which - Ar is a phenyl group of the formula Image a pyridyl group or a thienyl group; - R1 and R2 are each independently hydrogen, a halogen - 30 - atom, a hydxoxyl group, a C1-C4 alkyl group, a C1-C4 alkoxy or the trifluoromethyl group; -R3 is a linear or branched C1-C5 alkyl, a group -CH2- C6H5 or a group -CH2-CH2-C6H5; and -R4 is the group Image in which ? X is a linear or branched C1-C6 alkylene and ? R5 and R6 are each independently hydrogen or a linear or branched C1-C4 alkyl or form, with the nitrogen atom to which they are bonded, a hetero- cycle selected from pyrrolidine, morpholine or piperidine; or -R4 is a group selected from Image in which n is as defined above and R7 is hydrogen or a C1-C4, preferably C1-C2, alkyl group; Image in which n is as defined above, Image Image Image or and its salts with mineral or organic acids. The invention compounds have a valuable activity as M1- type cholinergic receptor ligands.
Boigegrain Robert
Brodin Roger
Kan Jean-Paul
Olliero Dominique
Wermuth Camille-Georges
Sanofi
Sim & Mcburney
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