6-amidino-2-naphthyl benzoate compounds

C - Chemistry – Metallurgy – 07 – D

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C07D 239/14 (2006.01) C07C 279/18 (2006.01) C07D 233/46 (2006.01) C07D 233/50 (2006.01) C07D 233/88 (2006.01) C07D 235/30 (2006.01)

Patent

CA 1254205

ABSTRACT OF THE DISCLOSURE Amidine compounds of formula (I) Image (I) and the pharmaceutically acceptable acid addition salts thereof are novel and are of use as anti-trypsin, anti- plasmin, anti-kallikrein, anti-thrombin and anti-complement agents which may be administered orally. These amidine compounds can be produced by the reaction between a carboxylic acid compound of formula (II) (II) Image or a reactive intermediate thereof and 6-amidino-2- naphthol of formula (III) Image (III) or preferably an acid addition salt thereof.

486773

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