6-amidinopenicillanic acid derivatives including the radical...

Details 6-amidinopenicillanic acid derivatives including the radical... 6-amidinopenicillanic acid derivatives including the radical...

C - Chemistry, Metallurgy

07

D

260/110

C07D 499/32 (2006.01) C07D 499/00 (2006.01) C07D 503/00 (2006.01) C07D 519/00 (2006.01)

Patent

CA 1144540

ABSTRACT OF THE DISCLOSURE Novel compounds are provided herein which are of the general formula I: Image I in which R1 stands for a five- to ten-membered azocycloalkyl or azabicyclo- alkyl residue attached via the nitrogen atom and optionally being sub- stituted by one or two, the same or different, lower alkyl groups; R2 represents a hydrogen atom or a lower alkyl, aryl or aralkyl radical; and A represents a radical of a .beta.-lactamase inhibitor containing a .beta.-lactam ring as well as a carboxy group, A being connected vla the carboxy group. Such compounds are useful in the treatment of bacterial infections. The new compounds are in particular strongly active against .beta.-lactamase pro- ducing bacteria.

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