6-amino-6-desoxyfumagillols, production and use thereof

Details 6-amino-6-desoxyfumagillols, production and use thereof 6-amino-6-desoxyfumagillols, production and use thereof

C - Chemistry, Metallurgy

07

D

167/208, 167/243

C07D 405/14 (2006.01) A61K 31/335 (2006.01) A61K 31/395 (2006.01) C07D 303/36 (2006.01) C07D 405/04 (2006.01) C07D 407/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2011448

The present invention relates to a compound of the formula: (see formula I) wherein R1 is 2-methyl-1-propenyl group or isobutyl group; R2 and R3 are each hydrogen atom, an optionally substituted hydrocarbon residue or an optionally substituted acyl group or R2 and R3 may form a ring together with the adjacent nitrogen atom; and the bonding mark ~ means .alpha.-linkage or .beta.-linkage, or a salt thereof. The compound (I) of the present invention has, among others, angiogenesis inhibiting activity, cell-growth inhibiting activity and immune reaction inhibiting activity, thus being useful as medicines, etc.

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