6'-amino-spiro (cycloalkane-1,2-penam)-3'-carboxylic acid...

C - Chemistry – Metallurgy – 07 – D

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C07D 499/00 (2006.01)

Patent

CA 1080697

ABSTRACT OF THE DISCLOSURE: 6'-Amino-spiro [ cycloalkane-1,2'-penam ]-3'-carboxylic acid derivatives having the formula Image wherein n i5 a whole number of from 3 to 6 and R1 represents a hydrogen atom and R2 is a radical selected from the group consisting of 2-phenylacetyl, 2,6-dimethoxybenzoyl, 2-amino-2- phenylacetyl, 5-methyl-3-phenyl-4-isoxazolecarbonyl and 2-carboxy-2-phenylacetyl radical and their pharmaceutically acceptable, non-toxic salts, have valuable antibacterial properties and are useful as therapeutic agents in the treatment of infections diseases caused by Gram-positive and Gram-negative bacteria. Processes for preparing these compounds are also described.

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